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刘芳

时间:2018-09-14 14:06  作者: 文章来源: 点击:[]

     

刘芳校聘研究员,杏林青年学者

邮箱:fangliu0602@gmail.com; fangliu@gzucm.edu.cn

导师类别:硕士生导师

研究方向:小分子/纳米探针技术,生物有机化学

Homepageshttp://fangliu0602.wixsite.com/fang-liu;

http://www.escience.cn/people/fangliu/index.html


个人简述

刘芳男,湖南邵阳人。广州中医药大学热带医学研究所杏林青年学者(校聘研究员)。2010年本/硕毕业于兰州大学,2014年博士毕业于南洋理工大学化学与生物化学系,曾先后在德国乌尔姆大学有机化学所,美国斯坦福大学化学系从事博士后研究。201712月入职广州中医药大学热带医学研究所。主要研究兴趣:新型小分子/纳米探针的制备及其在生物分析上的应用;药物的化学生物学研究等。近年来,以第一作者或通讯作者在Angew. Chem. Int. EdNanoscaleChem. Commun等国际著名期刊上发表SCI论文多篇,署名文章他引次数>700, h 指数14。担任Nano-micro Lett.Nanoscale Res. Lett; Analytical Chemistry;Bioconjugate Chem.; Molecules 等多个SCI期刊的审稿工作。

教育及研究经历:

2017.12 ~校聘研究员,广州中医药大学热带医学研究所

2015.07 ~ 2017.06   博士后,斯坦福大学化学系/医学院

2014.08 ~ 2015.05   博士后,乌尔姆大学有机化学所(Ulm,德国)

2014.02 ~ 2014.07   研究助理,新加坡南洋理工大学化学与生物化学系(NTU-CBC

2010.01~ 2014.01   博士研究生,新加坡南洋理工大学化学与生物化学系(NTU-CBC

经费来源:

2.国家自然科学基金青年基金项目 2019/01-2021/1225万主持

1. 高水平大学建设杏林人才科研配套经费,2017/12-2020/11   100万 主持

发表论文:

28.J. Lou ,F. Liu , C. Lindsay,  O. Chaudhuri  S. C. Heilshorn,  Y. Xia*. Dynamic Hyaluronan Hydrogels with Temporally Modulated High Injectability and Stability Using a Biocompatible Catalyst. Adv. Mater.2018. https://doi.org/10.1002/adma.201705215

27. Lyu, L.;Liu, F. *; Wang, X.; Hu, M.; Mu, J.; Cheong, H.; Liu, G.; Xing, B. *, Stimulus-Responsive Short Peptide Nanogels for Controlled Intracellular Drug Release and for Overcoming Tumor Resistance. Chem –Asian J.2017, 9, 14627-14634.(Co-corresponding author)

26. Liu, F.; Lou, J.; Hristov, D., X-Ray responsive nanoparticles with triggered release of nitrite, a precursor of reactive nitrogen species, for enhanced cancer radiosensitization. Nanoscale2017, 9, 14627-14634.

25. Ai, X.; Lyu, L.; Zhang, Y.; Tang, Y.; Mu, J.; Liu, F.; Zhou, Y.; Zuo, Z.; Liu, G.; Xing, B., Remote Regulation of Membrane Channel Activity by Site-Specific Localization of Lanthanide-Doped Upconversion Nanocrystals. Angew Chem Int Edit2017, 3031-3035.

24. Wu, X.; Liu, F.; Wells, K. L.; Tan, S. L.; Webster, R. D.; Tan, H. S.; Zhang, D.; Xing, B.; Yeow, E. K., Interplay of Hole Transfer and Host–Guest Interaction in a Molecular Dyad and Triad: Ensemble and Single‐Molecule Spectroscopy and Sensing Applications. Chem–Eur. J.2015, 21, 3387-3398.

23. Lu, S.; Liu, F.; Xing, B.; Yeow, E. K., Nontoxic colloidal particles impede antibiotic resistance of swarming bacteria by disrupting collective motion and speed. Phys Rev E 2015, 92 (6), 062706.

22. Cai, Z.; Jing, X.; Tian, X.; Jiang, J.; Liu, F.; Wang, X., Direct and indirect in vitro plant regeneration and the effect of brassinolide on callus differentiation of Populus euphratica Oliv. S Afr J Bot 2015, 97, 143-148.

21. X. Li, J. Mu, F. Liu, E. W. P. Tan, B. Khezri, R. D. Webster,E. K. L. Yeow,* and B. Xing* Human Transport Protein Carrier for Controlled Photoactivation of Antitumor Prodrug and Real-Time Intracellular Tumor Imaging.Bioconjugate Chem. 2015, 26, 955-961.

20. F. Liu*, J. Mu, B. Xing*, Recent Advances on the Development of Pharmacotherapeutic Agents on the Basis of Human Serum Albumin. Current Pharmaceutical Design2015, 21, 1866. (Co-corresponding author)

19. J. Mu, F. Liu*, M. S. Rajab, M. Shi, S. Li, C. Goh, L. Lu, Q. Xu, B. Liu, L. G. Ng, B. Xing*, Small Molecule FRET Reporter for Real-time Visualization of Cell-Surface Proteolytic Enzyme Functions. Angew. Chem. Int. Ed, 2014, 53, 14357. (Co-corresponding author).

18. F. Liu, J. Mu, X. Wu, S. Bhattacharjya, E.K.L. Yeow*, B. Xing*, Peptide-PeryleneDiimide Functionalized Magnetic Nano-platforms for Fluorescence Turn-on Detection and Clearance of Bacterial Lipopolysaccharide., Chem. Commun. 2014, 50, 6200. Featured as front inside cover.

17. F. Liu, J. Mu, B. Xing*, pH Responsive Small Molecule Peptide Nanogels: Strategies toward Overcoming Tumor Resistance and Controlled Intracellular Drug Redistribution. Abstract of ICMAT 2013, and Manuscript.

16. J. Li, F. Liu, Q. Shao, Y. Min, M. Costa, E. K. L. Yeow,* and B. Xing* Enzyme-Responsive Cell-Penetrating Peptides Conjugated Mesoporous Silica Quantum Dots Nanocarriers for Controlled Release of Nucleus-Targeted Drug Molecules and Real-Time Intracellular Fluorescence Imaging of Tumor Cells. Adv. Healthc. Mater.2014, 3, 1230. Featured as cover paper.

15. Min, Y.; Li, J.; Liu, F.; Padmanabhan, P.; Yeow, E.K.L*; Xing, B*. Recent Advance of Biological Molecular Imaging Based on Lanthanide-Doped Upconversion-Luminescent Nanomaterials. Nanomaterials, 2014, 4, 129.

14. X. Wu, F. Liu, K. L. Wells, S. L. J. Tan, R. D. Webster, H-S. Tan, B. Xing* and E. K. L. Yeow* Interplay of Hole Transfer and Host-Guest Interaction in Molecular Dyad and Triad: Ensemble and Single-Molecule Spectroscopy and Sensing Applications. Chem. Eur. J.2014, 21, 3387

13. Yang, Y.; Liu, F.; Liu, X.; Xing, B*. NIR Light Controlled Photorelease of siRNA and Its Targeted Intracellular Delivery Based on Upconversion Nanoparticles. Nanoscale  2013, 5, 231.

12. G. Zhou*, F. Liu, J. Wan, J. Wang, D. Wang, P. Wei, P. Ouyang. Design, Synthesis and Evaluation of a Cellular Stable and Detectable Biotinylated Fumagillin Probe and Investigation of Cell Permeability of Fumagillin and Its Analogues to Endothelial and Cancer Cells. Eur. J. Med. Chem. 2013, 70, 631.

11. Y. Min, J. Li, F. Liu, E. K. L. Yeow*, B. Xing*. Near-Infrared Light Mediated Photoactivation of Platinum Antitumor Prodrug and Simultaneous Cellular Apoptosis Imaging via Upconversion Nanoparticles.Angew. Chem. Int. Ed. 2013, 52, 1.

10. S. Lu, W. Bi, F. Liu, X. Wu, B. Xing and E. K. L. Yeow*, Loss of Collective Motion in Swarming Bacteria Undergoing Stress. Phys. Rev. Lett. 2013.111, 208101.

9. G. Zhou*, Z. Weng, X. Shao, F. Liu, X. Nie, J. Liu, C. Wang, K. Guo. Discovery and SAR Studies of Methionine-Proline Anilides as Dengue Virus NS2B-NS3 Protease Inhibitors. Bioorg. Med. Chem. Lett. 2013, 23, 6549.

8. F. Liu, A. Y. Ni, Y. Lim,  H. Mohanram, S. Bhattacharjya* and B. Xing*. Lipopolysaccharide Neutralizing PeptidePorphyrin Conjugates for Effective Photoinactivation and Intracellular Imaging of Gram-Negative Bacteria Strains. Bioconjugate Chem. 2012, 23, 1639.

7. J. Teguh, F. Liu, B. Xing*, and E. K. L. Yeow*. Surface-Enhanced Raman Scattering (SERS) of Nitrothiophenol Isomers Chemisorbed on TiO2. Chem. Asian J. 2012, 7, 975.

6. Q. Zhang, F. Liu, K. T. Nguyen , X. Ma , X. Wang , B. Xing , Y. Zhao*.  Multifunctional Mesoporous Silica Nanoparticles for Cancer-Targeted and Controlled Drug Delivery.  Adv. Funct. Mater. 2012, 22, 5144.

5.  Yang, Y.; Aw, J.; Chen, K.; Liu, F.; Padmanabhan, P.; Hou, Y. L.; Cheng, Z.; Xing, B.* Enzyme Responsive Multifunctional Magnetic Nanoparticles for Tumor Intracellular Drug Delivery and Imaging. Chem. Asian J. 2011, 6, 1381.

4. Zhang, W., XU, J.: Liu F.; Li, C.; Jie Y.;  Chen, S.; Li, Z.; Liu J.; Chen, L.; Zhou, G.* Heterodimers of Histidine and Amantadine as Inhibitors for Wild Type and Mutant M2 Channels of Influenza A. Chin. J. Chem. 2010, 28, 1417

3. Liu, F.;  Wan, J.;  Chen, S.;  Lu, X.;  Wang, X.Y.;  Zhou, G*.  Synthesis and in vitro Tests of Two Biotinylated Fumagillin Derivatives. World Sci-Tech R & D (a Chinese Journal), 2010, 32, 699.

2. Liu, F.; Li, Y.  A Primary Investigation into the Phyllotaxy Related Asymmetry on the Organs of Althea Rosea and BrassiaChinensis. Journal of Life Sciences. 2010, 4, 14 (a Chinese Journal).

1. Liu, F.; Li, Y. A Primary Study on the Tricotyledon Mutant of Dianthus plumarius. Highlights of Sciencepaper Online. 2010, 3, 2000. (a Chinese Journal)

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